Demi-Lee Simpson was last seen in Stirling on Friday boarding a train to Aberdeen.
The 16-year-old was seen getting on a train at the station in Stirling at around 8am.
Demi-Lee is described as being 5ft 6ins tall with long fair hair.
When she was last spotted she was wearing North Face branded black leggings with a blue and white hooded top.
Police are appealing to the public for help in finding the missing teen.
Anyone who believes they have seen Demi-Lee or who has information regarding her whereabouts should contact police on 101 quoting incident number PS-20220325-409.